Social media to denounce drug pricing being unreasonable died down。
September 2015, US presidential candidate Hillary Clinton hastened to bring claims drive up the price of a particular drug acts surgery – alluding to in the industry as a pest Shike Lai (MartinShkreli), he was in charge of the Turing pharmaceutical company (TuringPharmaceuticals) just a there are decades of history, part of the essential AIDS drugs to let the market caught in a passive, the night before the drug price increase to $ 750 dollars from each and。
  While Hillary Clinton issued a limited threat from the presidential election more than a year, but FACTSET biotech stocks index fell one week 17%。 In contrast, the President of the United States in early March at the Trump issued a document that will implement an extensive program of enhanced pharmaceutical competition: "American drug prices will drop!"A week later biotech stocks was up 1%。
  Why this time results to differ materially?Perhaps investors believe that Trump and too pro-business Republicans, will not release the pharmaceutical industry profits drop policy。 Or perhaps because, after so many years of drug prices soaring, investors believe that reform is too difficult, pharmaceutical industry lobbyists forces are too strong。   Investors should think again。
Changes in drug prices will slow growth in the next few years is already in progress。 Some of these changes are subject to market changes, without the need of politicians to take action。 Other changes only need to fine-tune the policy, not completely fresh start。
Until recently, investors profited rose in a series of stocks, such as (Abbvie), (Amgen) and genetic。 But now they are to be alert。
In turn, to favor those whose income depends mainly on the introduction of new drugs, the company's patient population growth, such as renewable yuan (RegeneronPharmaceuticals) and VertexPharmaceuticals。   According to Pharmaceutical Payment Management (PBM) ExpressScriptsHolding, since 2008, the most widely used brand-name prescription drug prices increased by 208 percent, compared to the same period consumer prices rose only 14%。
During this period generic drug prices have fallen, but limited to reduce the pressure on drug prices: although the United States issued patent medicines account for only 10% of prescription drugs, but drugs accounted for 72% of total expenditure。
Abbvie of rheumatoid arthritis drug Humira (Humira's) is the world's best-selling drug, with sales of $ 16 billion last year, which is a typical example of how synthetic biology drug prices Yiqijuechen。
Different drugs with the traditional chemical synthesis, biological synthesis of biopharmaceuticals made。   Humira sold in the form of injections, the price of a needle from 2008 to nearly $ 700 up to $ 2200 today。
The main patent on the drug expired last year, but in January this year, Abbvie announced drug price increases of 8% – the same day, US Secretary of Health and Human Services nominee Price (TomPrice) response to Congress on drug prices rose questioned。
  Drugs planning department and other payers to negotiate drug prices discounted drug prices。 Even so, the United States Humira discounted price is more than twice as Canada and France。
  Development of new drugs, especially expensive biological drug development, in order to encourage innovation in the industry, it is necessary to implement high drug prices。
However, according to an analysis report "Journal of the American Medicine" (JournaloftheAmericanMedicalAssociation) published last year, the number of R & D costs associated with the signs of drug prices does not exist, the US pricing of prescription drugs is mainly to see the market will bear。
  The market will bear a lot of things。 Promote drug prices drop two key strength is the strength of competition and drug price negotiations between the payer drugmakers。
From 2010 to 2012, an unusually large number of brand-name drugs lose patent protection, a relatively modest increase drug prices。
Theoretically biotech drugs more intense competition。
By 2020, seven big selling drug patents will expire。   For example, last year only to lose the Abbvie Humira synthetic patent。
There are 70 kinds of other patent medicine: 20 producing several patents, patent 10 kinds of pharmaceutical preparations, as well as dozens of indications, therapy Patent。 When briefing to investors, Abbvie claiming at least 2022 years ago can avoid competition。
Abbvie Amgen sued for patent infringement to prevent the latter to launch a biosimilar。   It is not clear how noisy protest Amgen, the company itself is jump "patent ballroom dancing" Protecting arthritis drug Enbrel 2015 Annual lose the main patent。
Professor at Harvard Medical School, one of the aforementioned "Journal of the American Medical" report author JerryAvorn that the company is more brazen, aggressive, not only to pursue these strategies, but this boast。   FederatedInvestors portfolio manager MartinJarzebowski said patent expiration will not only make the second reason is the decline in drug prices, biopharmaceutical very difficult, only a few companies have the appropriate size and expertise。 Compared with traditional generics, biosimilars development, greater manufacturing, marketing costs。 And because biosimilars similar brand-name drugs rather than brand-name drugs precise replication, companies must allow doctors to believe that biosimilars exactly the same effect with the original study medicine。 In a recent competitive analysis report bio-generic drugs is expected, biosimilars market profits would fall short of Wall Street expectations。   Other sources of pressure drug prices – the bargaining power payers – as great as in other countries in the United States。
Other countries decided to experts appointed by the Commission to implement universal health care system of drug price negotiations, acceptance made in accordance with the effect of drugs or medicines rejected。 The United States has a lot of drug prices payers, including Medicare (health care) and Medicaid PBM (medical) institutions, the private health insurance companies and ExpressScripts, CVSHealth (CVS, like UnitedHealth Group。
Medicare spending accounted for 29% of total pharmaceutical expenditure, but the law of that system agencies shall negotiate drug prices d drugs, and Medicare must cover most of the drugs – this is a concession to fears that the government made offside Members。 At the same time PBM to use its purchasing power to obtain a discount drug prices, but these companies sometimes also by certain drugs into the drug list and get a discount from pharmaceutical companies, resulting in a conflict of interest。
  According to reports, Trump institutions to support Medicare to negotiate drug prices, which could make Trump with congressional Republicans and not difficult by the relevant Act。 Fortunately, simpler way to control drug prices increased presence, some of which way the industry has been in practice。   For the prices of medicines which make more reasonable and effective evaluation is a good starting point for control of drug prices。
Over the years, "Consumer Reports" (ConsumerReports) published a straightforward opinion in this regard, for example, which treat asthma inhaled steroids highest price。 For more complex drugs, by the United States Institute of Economic evaluation of clinical (InstituteforClinicalandEconomicReview, ICER) assessment。 Clinical data for research ICER of doctors and researchers, writing including synthetic drugs, including biopharmaceuticals comparative study。
As the saying goes health is priceless, but the ICER is the use of quality adjusted life years, called (QALY) standardized measure of the value of drugs。 QALY = 1 represents full health life year。
  For example, ICER a recent report on rheumatoid arthritis immunomodulatory drugs, he said the old analogy found a drug more effective drug, but its price was too high。
With the QALY measure, Humira highest price for every $ QALY23 million and the monoclonal antibody was $ QALY20 per million and Roche's Actemra about every ten thousand dollars。
The report concluded that Humira drug prices need to fall by 50% -69% was reasonable。
  ICER of funds provided by non-profit organizations, the growing influence。 Last year Medicare pilot announced that the competent authorities report quoted ICER of different payment methods B drug, known as an example of the department is exploring the reasonable pricing of medicines。 B medicine is a doctor's office or hospital outpatient department issued drugs, such as certain cancer drugs。
New York and ICER were related to explore, and later governor Cuomo (AndrewCuomo) announced a proposal in January this year, the establishment of a drug utilization evaluation committee to evaluate the fair price of expensive drugs。 2015 ICER published right, regeneration and $ Amgen price hereditary high cholesterol PCSK9 inhibitor drug jointly manufactured questioned the report, PBM will be less willing to pay。
  As it now appears Amgen drugs and existing drugs do comparative tests of new evidence, said it would review its analysis ICER。
At the same time renewable yuan CEO Shi Leifu (LenSchleifer) investigate new drugs Dupixent atopic dermatitis and contact ICER fair price。
Renewable yuan final price of the drug at the low end of the price range given fair ICER recommendations, significantly lower than those of atopic dermatitis-label prescription drug prices, including Humira (arthritis and skin itching belong inflammation)。   ICER founder Pearson (StevenPearson), said regeneration yuan examples fully illustrate some pharmaceutical companies are admitted the situation had changed。 Renewable yuan not to increase the price of the best-selling drug Eylea, Eylea 2011 approved eye disease wet age-related macular degeneration drug。
Shi Leifu years of industry status quo criticism。
He said last week, referring to the correspondents drug prices rose, some people turn a blind eye to this, the Constitution limited patent protection time。   Nevertheless, Dupixent pricing marks a departure from the old way of。 Shilei Fu said in the past pricing model is to make a decision, then the reasons; Dupixent pricing is we decided to organize talks payer, PBM and ICER like, come up with a reasonable price we think。   Patients also need more competing drugs。
In January, the independent Senator Sanders (Bernie Sanders) proposes to allow pharmaceutical distributors and pharmacies import prices lower drug bill, narrowly passed by the Senate – to get 12 Republican senators in favor, which is traditional front of a sign of being transferred。
Another view is to prevent severe early patent medicines, to stop "patent ballroom dancing" (patentdance) phenomenon。   JanneyMontgomeryScott pharmaceutical market analyst DebjitChattopadhyay believe that this approach may not be implemented recently, but whatever it is a goal, a comprehensive health care reform much more difficult。
US Food and Drug Administration (FDA) must address the backlog of generic drug applications, and signed a reciprocal agreement with the European and other strict control of the drug market。
European market launch of biosimilars is much faster than the United States。
Drug regulatory authorities may also expand the category, allowing the use of similar effect, but not necessarily fully replace similar drugs。
  Whether driven by members, employers or trade unions, PBM transparency must be improved。 With plenty of alternative medicines and fuller information on drug prices, PBM and health insurance plans side will have the ability to enter into contracts more favorable, an analyst at investment bank LeerinkPartners Boggs (GeoffreyPorges) think this is a key way to significantly control of drug prices one。
Porges said, must enable them to say, "This is the same two drugs, the drug kicked out, leaving a kind of medicine."。 Such as arthritis?The price of drugs has decreased significantly, to less than $ 40,000 per patient from $ 90,000。 This aspect can look at the example GileadSciences, most of the company made a profit of arthritis?Drugs contributions in the past year its share price has fallen by a third。   GileadSciences is an extreme example, but it is possible slowdown in drug prices put pressure on pharmaceutical stocks。
Since October last year, prescription drug prices have edged down。
Biotechnology and traditional pharmaceutical industry profit is expected to continue to drop。
If the price drops extensive growth, the rapid price increases of companies or difficult to keep Wall Street's expectations。
Boggs research has pointed out, Abbvie, Amgen, Biogen and other traditional pharmaceutical companies relatively aggressive growth in drug prices。
  Renewable yuan is another scene, although the company in the past did not mention how the price, but is expected the next few years will be double-digit percentage growth in earnings per share。
Drug Approval Dupixent dermatitis which is possible to obtain a plurality of treating allergic disorders (including asthma)。
Reproducing element 28 times the current price-earnings。   Vertex is another example of biotechnology companies win by patients and drug prices too high and rising rapidly。 Because cystic fibrosis drug test two together to get a positive result, it is possible through the approval, the company's share price this year rose more than 50% of the cumulative。
  The two drugs with more vertices now cystic fibrosis drug efficacy Orkambi slightly forward, shortness of breath, can significantly reduce the incidence of side effects。
Vertex also tested a triple drug is expected data released later this year, it is possible to make the company achieve greater progress in cystic fibrosis drugs。
Vertex year after adjusting for stock compensation expected earnings per share of $ only, but within five years, analysts expect earnings per share of more than $ 700, the pursuit of growth stocks for investors reasonable stock price。
  More generally, however, the rapid growth in the number of patients is difficult enlisted, drug prices rose less dependent on the core pharmaceutical company, which is a problem。 Past due to a significant increase in profits in the industry and favored investors may need to reduce exposure。   Asthma nebulizer medication albuterol (salbutamol) 40 years ago for the first time by the launch, then known as salbutamol (albuterol)。
Recently listed a generic drug albuterol, 200 priced at $ 21。
In the United States there is no generic albuterol, only salbutamol, PROAIR of drugs。 200 PROAIR atomized drug US drug price comparison website recently listed for $ 67 US dollars -80。
  Why such a big price gap?In the United States, FDA since mid-2009 to disable the chlorofluorocarbons used as aerosol propellants。
Originally from asthma aerosol phase out chlorofluorocarbons (destruction of the ozone layer) extensive program of impact, because these drugs are important asthma medication, and the release of chlorofluorocarbons much。
  Pharmaceutical companies smell opportunity from which new patents reportedly has successfully lobbied the FDA to abolish asthma aerosol exemptions。
Today, the United States use a hydrofluoroalkane as a propellant。
Environmental concerns pharmaceutical giant to generate returns。
Ventolin is expected this year will bring GlaxoSmithKline million (US $ 0.1 billion) in revenue, up 5% compared with 2016。   Another asthma drug Seretide (ADVAIR) containing steroids and bronchodilators, is used for daily asthma prevention。 The main drug patent expires in 2010, Diskus inhaler of discoid patent expires this year。
It is available for one month using the minimum dose of Seretide Diskus is priced at more than 350 US dollars。 Mylan company has a generic Seretide ready to launch, but it is not clear when the drug is approved for sale。 Generic drug companies must first prove its precise dose inhaler。
  A year ago researchers published a research article in the journal "Clinical Pharmacology and Therapeutics" (ClinicalPharmacologyTherapeutics), said different batches inhaled dose of Seretide。
This creates a problem, namely how generic drug companies to prove their bioequivalence inhalation device in itself, even Seretide bioequivalence unclear circumstances。
(Lemon Nan / compiler)。

  Chinese say, "Zhao Jia is more than blood."。
The white spots, suggesting that human organs dysfunction, especially in poor digestion and absorption, the body nutrition is not enough to pay attention to a balanced diet。
  With Shu Wen prompt physical state of fatigue, may have recently not very good mental state。In any case, pay attention to relax, rest a regulation。  Dysfunctional organs causes: 1.With cold, wet, hot evil-based (including bacteria, viruses), improper sexual intercourse, excessive birthing, eating disorders, trauma or flutter caused by dysfunctional organs。  2.The human spirit emotional (impassioned) changes can affect organs, blood functional activities。Mental or emotional stimulation, can affect the function of regulating Chong and Ren。
  The main symptoms of kidney, liver, heart, spleen dysfunction, resulting in blood deficiency, any lack of red, with a pulse is not solid; inherent loss of kidney essence, acquired disorders, wasting stomach, blood deficiency after serious chronic illness and other organs are dysfunctional performance。  Prevention: 1.Correct understanding and stable natural law of development is the advent of menopause mood irreversible, should equanimity。
  2.Adjust your diet, increase activity with age, basal metabolism decreased, the need to reduce heat, so the diet must be reasonable adjustments。
  3.Pay attention to hygiene, regular check-ups status。
  Relieve fatigue small coup eat lots of green vegetables。
They contain important minerals and vitamins, the body needs these substances to fight fatigue。Green leafy vegetables are rich in potassium, which is an important element of fatigue resistance, (bananas may be)。The calcium to ease fatigue and stress also play an important role。  Drink a glass of grape juice and lemon juice can prevent and relieve mental fatigue every day。Grape juice has been shown to dispel fatigue。Therefore, after the end of a tiring day's work, you may wish to have a drink, relieve fatigue。You can also pour the lemon juice and grape juice in a cup to drink, taste better。
  Bubbles per day。You can add 7 drops of lavender essential oil in the bathtub, 3 drops of rosemary essential oil, 3 drops of peppermint essential oil, a cup of sea salt, a cup of soda。This recipe can relieve fatigue, hot bubble bath, you will be a lot of cool。
  For fatigue, it is not necessarily a good rest。On the fatigue, and some may be caused by psychological factors mental fatigue。Therefore, we must pay attention to adjust their state of mind in their daily life and work, a time to relax, not been in a state of high pressure。

The students are pro forma for map / China Taojiang net Yesterday was World TB Day。
Have less than 100 days from the national college entrance examination, fourth Taojiang County, Hunan Province 364 high school class 78 students suffering from tuberculosis are still worried about whether they pass the college entrance examination。   Mid-August 2017, the class gathered tuberculosis epidemic outbreak。 Several sick students told Beijing Youth Daily reporter, and now they are still taking medicine。
  Students consider the practical difficulties of illness, Hunan Provincial Education Department has agreed to sick students the college entrance examination was delayed two months。
  78 students enrolled in this year's college entrance examination in August 2017, Taojiang 364 Fourth Class outbreak of tuberculosis clusters of disease, due to the prevalence of students are graduating high school students, college entrance examination approaches, their situation cause for concern。 According to the local government informed that as at March 19, 2018, the Fourth Middle School students Taojiang total of confirmed cases of tuberculosis in 79 cases, 78 students have enrolled in the college entrance examination, apply for leave of absence procedures 1 person。 78 students have been back to school enrolled 59 students, four people were hospitalized, six people drop out treatment, eight people can not return to school back to school and one review。
  Since suffering from tuberculosis, 364 of the original class of Chen Xin (a pseudonym) has not been back to school, the family invited a tutor to help her private tuition。 Seeing entrance day draws near, a recent review of the college entrance examination left her dream cast a shadow。 "In early March to review when the doctor told me I have to eat at least a year drug, because empty lungs have not healed。
"Chen Xin said he did not know he could not pass a medical examination before the college entrance examination, even if passed, the next university entrance examination also made her very worried。
  Li Ching (a pseudonym) is a classmate Chen Xin, she is now back to school to study, but how much influence the physical condition or results。 And Chen Xin, she also continues to medication, "at least have to take medicine for two months, and lung scars, do not know will not affect the physical"。   Hunan Provincial Education Department agreed to defer examination in late February this year, Hunan Province issued the relevant provisions of the 2018 college entrance examination work, medical standards refer to "ordinary colleges and universities admissions examination guidance," the Ministry of Education, Ministry of Health, China Disabled Persons' Federation issued ( teaching [2003] No. 3)。
  Beijing Youth Daily reporter found the relevant provisions on TB in the above document。
Tuberculosis following exceptions may not be accepted: primary pulmonary tuberculosis, infiltrative tuberculosis induration stable; tuberculous pleurisy model has been cured or cured sequelae pleural hypertrophy。
All extrapulmonary tuberculosis (renal tuberculosis, bone tuberculosis, peritoneal tuberculosis, etc.), after hematogenous disseminated tuberculosis cure without recurrence at least one year, after more than two hospitals (or tuberculosis control) no change specialist examination。
Lymph gland tuberculosis have asymptomatic clinical cure。
  In order to avoid suffering from tuberculosis because students will not affect college admission, Hunan Provincial Education Department has agreed to postpone the June 14 Zhong Taojiang four sick students to the examination time。   Hunan Provincial Education Department staff told reporters Beiqing Bao, the first time they verified the situation after learning of the outbreak of tuberculosis epidemic Taojiang four high school students, followed by a group of these students' college entrance examination deadline postponed from April 15 to 6 January 14。 Taojiang county government then issued a document called, "and strive to by more than two months of treatment, to the college entrance examination standards。 "Experts say the cure does not affect the high Mengqiu Institute of Tuberculosis and Thoracic Tumor tuberculosis two kinds of medical director told reporters in Beijing, the vast majority of TB patients after standard treatment can be completely cured, but depending on the condition, the treatment required time there will be differences: "for the first time the prevalence of major anti-TB drugs and sensitive groups, requires a minimum treatment period of six months; for retreatment of tuberculosis patients take eight to nine months; and MDR-TB cure general in about two years。
"There is not only the requirements of the college entrance examination in patients with pulmonary tuberculosis restrictions, the reporter found that China in 2013 introduced the" prevention and control management approach "clearly states tuberculosis, schools at all levels, faculty and school freshmen nurseries, food, medicine cosmetic practitioners, practitioners and other provisions "public places, health regulations," the groups are the focus of tuberculosis screening population。
  In this regard, high Meng Qiu explained, TB only to be found by chest X-ray examination of the project in general admissions or employment physical examination, and will not affect other indicators。
After cure the disease, TB is killed, leaving lesions if they are completely absorbed, do not see shadows on chest X-ray, it can not be learned whether volunteers has won tuberculosis。
If the disease is discovered late, not quite fully absorb it, although the latter completed treatment and sputum examination and other related checks were negative, but still be able to see traces tuberculosis suffered from a chest X-ray, such as fiber sclerosis lesions or calcifications。
  But high Mengqiu adds both cases call a cure, will not become an obstacle to personal and social studies admission employment, but had received norms need to provide proof of anti-TB treatment to the authorities, chest X-ray or CT findings of previous and sputum examination results。
  Text / reporter Zhang Xiong Yingqi month deceive。

  Barcelona star Pique Manchester United have had a brief career, recalled those years the Red Devils, Pique most fear figure was the Manchester United captain Roy – Keane。
Recently, Pique broke through ThePlayersTribune interesting year in the Manchester United dressing room。
  "I was in the first game at Old Trafford, when everyone's getting ready in the locker room, I was very nervous。
You can think about that scene, I was a 18-year-old child, sitting in the little locker room wearing socks around that Ruud van Nistelrooy, Ryan Giggs, Ferdinand, I really want to stealth up。 I thought, to do my own thing, do not interesting。 So we sat, and other coaches come in lecture。
My position in Roy – Keane side, the locker room is too small, as small as our legs almost met, and that there is no space。 "" Originally the dressing room is deathly quiet, and suddenly you hear the sound vibration of the phone, very slight, Roy began looking all over the house。
I realized that my phone rang, I tune into shock, in my pants pocket, then stuffed into a laundry bag, hung on the wall behind Keane。
Roy did not find the source of the noise, he began looking around like a madman the whole house, he wanted to find out who in the end is。 You remember – Jack Nicholson in "The Shining" from rushing out the door shot it?Keane was just like。 "Pique continued:" Keane roaring "to everyone who phones?"No answer。
He asked again。 Still no answer。 He asked a third time, "in the end who TMD phone?'Finally, I spoke like a child, very softly said,' I'm sorry, my。
"Roy lost your mind。 Him in front of everyone crazy, it was so incredible。
I also almost crazy。
But in general, Roy is a good man。 "" It is 2018, and everything is different, all the children will play phone before the game。 But in 2006, but a different world。 You can not do that, especially at Manchester United can not do that, especially not do that in Roy's locker room。 That is one of many mistakes I committed in Manchester in a。

  Sina Wall Street Beijing 28 hearing speaking, the current US economic situation is closer to normal than at any time since the end of the Great Recession, but this is only "close" only, rather than a true return to normal。 This is a market observation judgment, they explains this special article。
  Although consumer spending has improved, but still below the pre-recession level, consumer confidence was much the same。   As for business, the pace of investment in mitigation, the more free cash flow into stock buybacks and dividends – there are many looking for ways to migrate headquarters overseas to avoid tax, caused the recent conferences and a variety of hot debate。   At the same time, federal, state and local governments have had to shrink spending。
  As a result, the unemployment rate by a full six years before returning to the level of mid-2006 before coming close to recession。   Even now, there are 15.7 million Americans unable to find full-time work, this figure compared with the same period in the history of other recovery, it is still at a high level。
Needless to say, millions of Americans have adequate skills for less than 65 years old, but have given up looking for work in the year, so that labor force participation rate is reduced to the lowest point since President Carter era。
  However, in mid-2015, although still made some modest, but steady progress is – this is the so-called new normal, it。
  US economic growth% each month, 200,000 jobs, so the unemployment rate down to the lowest post-recession era 5%。 Because narrow unemployed, the greater the pressure raises some companies even begin to face, average hourly earnings growth rate reached its fastest recovery。
  Car sales also hit a new high, although this is largely because the car used in the current age of the vehicle has reached record levels, many cars and trucks can not update。 Ultra-low interest rates and lax lending standards also played no small role。   At the same time, the real estate market continued out of the road to recovery after the collapse of the modern history of the most terrible。 A limited number of the residential buildings have been a lot better, builders has become the biggest problem with the lack of qualified technical workers, as well as meet strict standards of consumer lending。
  In this context, the Fed finally hands in December, the first time since mid-2006 has pressed the button to raise interest rates, ending the era of near-zero interest rates for up to seven years。
This era will last for so long, is precisely reflect the performance of the US economy is how the poor。
  "Growth should slow to some extent be attributed to the chaos of the post-crisis era。 Too bad the financial crisis。 People witnessing their friends have lost their jobs, lost their homes or were forced to take a pay cut。 "PrincipalGlobalInvestors chief global economist Bauer (BobBaur) explained," is the same business。
The Fed cut interest rates to zero, there is no stimulus is expected to play in, the key here。 "The last batch of economic reports in mid-2015 is expected to re-strengthen the impression that the situation is gradually improving, but even so, we are now the growth rate is still less than the historical average of%。
  December consumer confidence index will be improved, after all, the lowest gasoline prices over the years put in there。 First-time filings for unemployment benefits from the situation seems, the number of layoffs has been reduced to the lowest since mid-1973。 Residential sales are expected to rise again。   But, at the same time, the government is expected to trade probably would not be so ideal。 Strong dollar and a weak global economy determines the demand for US manufactured goods can not be strong, so that the interests of exporters suffer。   Manufacturing and other major US business sales and profits in the mid-2015 a lot of time has been the economic headwinds, due to poor performance, a direct impact on their desire to increase the number of employees。 This situation is expected to continue at least until early next year。
  Accompanied by moving closer to 2016, the most important issue is that we will once again suffered a bad winter weather, and had to once again face a bad first quarter?  US economy since 2010, the first quarter growth rate averaged only%。
In sharp contrast, there was the second to the fourth quarter, respectively%,%,%。
  If such a law once again fulfilled, then the Fed is difficult to quickly raise rates。 Instead, the Fed must also be repeated hair, he said he would remain calm, step by step, so it shows the attitude of the economy in the foreseeable future also needs support。   "As long as the US economic recovery is still falter, the Federal Reserve interest rates return to normal doomed journey will be long marathon。 "BankoftheWest chief economist Anderson (ScottAnderson) says。

What bloating bloating can not eat it almost all have a lot of experienced, cause bloating, poor diet is a factor which greatly。 So, bloating can not eat what Chinese medicine acupuncture massage which can effectively relieve bloating it with the small series together to look at it。
1 bloating can not eat anything fried foods fried foods are usually the same thing will be wrapped in batter and deep fried, that is, food became a bit hard for the digestive tract for food。
After the food after frying have become greasy and fatty foods, these two substances are harmful to the abdomen is。 If there is inflammation of the intestine itself, then, after eating greasy food, easy to cause symptoms of nausea or diarrhea, bloating easy it is proposed that people should try to eat less fried foods, such as fried chicken, french fries, etc.。
Eat chicken to eat healthier, then you may wish to change the method of cooking, to change cooking methods baked with bread crumbs or relative will be more healthy。
2, high spicy food spicy spicy food will disrupt the esophagus, but also cause bloating。
Taste more spicy red pepper, then eat if you have the feeling of heartburn, it is recommended to drink a bit of spiciness to reduce lactic acid, prone to some irritation of the stomach, causing bloating problems。 Recommendation stomach health problems had better eat less irritating heavy, spicy foods, in order to avoid further irritation of the stomach。
3 bloating can not eat anything chocolate talking about here is not a problem simply eating chocolate can cause bloating, eat the right amount of chocolate actually healthy also has certain advantages。 It is important not to eat too much, eat too much not only have obesity problems, but also lead to bloating。
Chocolate can cause lower esophageal sphincter to relax, causing acid reflux problems, especially in patients suffering from gastroesophageal reflux disease, but be careful not to eat chocolate, even just a small piece also may cause problems。

  Growth from a start, dental care should just be the baby's daily life。 However, there are a lot of people did not mind and luck。 They believe that "sooner or later to replace the deciduous teeth, then why not after permanent teeth care?"。 I tell you this may be wrong。
  If the permanent teeth cleaned properly, prone to corrosion or tooth decay, the baby is difficult to chew food, causing indigestion, can not develop proper eating habits, tooth decay and serious, inflammation will occur from the root portion will soon grow back deciduous adverse effects, can lead to poor calcification of permanent teeth, or the color and appearance of the tooth surface such as a difference。   When the baby was born six months, will begin to grow, and it lasts up to 3 years old, all 20 primary teeth will grow, and 6 years old then slowly began to grow on a permanent tooth, which is permanent。
For different month-old baby, there are different methods of maintenance, Mummy novice should learn the correct brushing step, in order to maintain the baby's teeth。   Second, 0?6 months baby – the baby did not have clean teeth during this period, although not grow teeth, but still clean mouth a day at least 2 times。
When the baby drinking milk, you should use warm water soaked gauze towels, carefully wipe the entire oral cavity to help baby。   Correct steps: firstly water should be fed baby, after rinsing the mouth, and then water soaked gauze towel packages on the index finger, positive wiping gums, inner, upper, lower, right, and left a。
  Rear side gums should gently rotated fingers, gently wiped, also above the gums gently wiped, and then massage the gums finger, the finger rotatable wiping palate, about 2 minutes massage。   Area between the gum and the lip is easy to leave the milk residue, and therefore need to be carefully wipe, but you can not wipe too hard, easy to make the mouth abrasions!  Third, 7?12 months baby – brushing habits to develop in this period, your baby will start to grow two bottom teeth and two upper teeth, front teeth begin to grow long after the tooth should carry out normal maintenance。
At this time, although they can not properly brush your teeth, but it is beginning to develop the habit of cleaning teeth period, during which time, Mommy can use a soft bristle toothbrush to clean the front teeth, so not only can wipe the teeth of residual dirt, but also massage effect。 After a day should brush your teeth at least twice, preferably at meals or drinking juice。   The correct procedure: first let the baby lying on the bed or thigh Mommy, Mommy can help make brushing baby from behind。
  Correct method of brushing: brush lightly down from the upper row of teeth on the lower row of teeth and brush from the bottom up, or vibration levels between two teeth can be cleaned at least 2 minutes。
  Fourth, 12?24 months baby – Carefully clean the baby molars to around 1 year old, will grow up and down four teeth, grow a total of eight; the baby was born 16 months or so, the following will start to grow two molars; born 20 months , each of the upper and lower canines will grow 2。
Be sure to use a toothbrush to brush your teeth carefully。
  The correct procedure: Let the baby this time holding a toothbrush own practice, but can not use toothpaste or mouthwash can dip water use, and finally by the mummy is still correct brushing baby。   Also let the baby lying on the bed or thigh Mommy, Mommy can help make brushing baby from the rear, upper row of teeth from top to bottom side lightly, lower row of teeth from the bottom up brushes, toothbrushes depression molar tooth will have to about face massage to the concave tooth surface clean。
  While brushing the right upper order to a lower left in brush rows of teeth, and then brushed back by a row of lower left upper right row of tooth surface, cleaning at least 2 minutes。

India is one of the world's fastest growing electronic business market currently, it develops its two local commercial enterprises Flipkart and Snapdeal, has recently spread to the largest shareholder of the largest local commercial enterprises Flipkart will become Wal-Mart, why has hope something Alibaba Indian market has not taken action yet?After the Chinese online market structure and stability, China's largest electricity provider Alibaba also choose to attack the Indian market, which had earlier invested in Indian electricity supplier snapdeal, in 2016, when it also intends to spread investment Flipkart, but because for various reasons did not become a reality。 The current Wal-Mart plans to buy a stake in Flipkart Flipkart from the old shareholders Tiger Global Fund and Softbank hands, while Flipkart issue of new shares to Wal-Mart, Wal-Mart will eventually hold 51% stake in Flipkart acquired a controlling position。 Wal-Mart is the world's largest retailer, but the booming years of online market is the steady erosion of its share of the retail market, forcing it to enter the online market。 Alibaba shares snapdeal disadvantaged in the past three years under fierce attack in India's largest local electricity supplier Flipkart and Amazon's market share declined, the gap between Flipkart and Amazon continues to expand, due to lack of competitiveness, one of the shareholders of Softbank had Flipkart and hopes to promote snapdeal merger, but snapdeal founder and other opposition failed to become a reality。
In addition to investment in shares and plans snapdeal shares Flipkart, Ali largest investment in India Paytm platform and its parent company one97, shares eventually held more than 51%, has a controlling stake after the Paytm, launched its electric Paytm business services, and its mode of Ali Lynx similar to brand-based electricity supplier, the main superior products are genuine。
Currently Paytm electronic business platform has settled in over one hundred thousand brands, many of which come from Chinese market, Paytm electronic business platform to help Indian consumers at preferential price to buy excellent quality and price of Chinese brand products, much time in the past year Paytm rapid development platform。
Softbank last year for $ 1.4 billion invested in Paytm, September Paytm acquired Bangalore-based travel booking site, showing that this appliance business platform won the favor of capital institutions, and began to mergers and acquisitions of the rapid expansion of business。 Perhaps Alibaba Holdings Paytm rapid development, it has no intention to invest in India's domestic electricity business platform, and want to support its holding Paytm electronic business platform to achieve rapid expansion has made certain market position in the Indian market objectives electricity supplier。 As can be seen from the Chinese market, after the electricity supplier in the market to a certain stage of development, B2C model Lynx is more popular with consumers, consumers can purchase this type of electronic business platform to guarantee a better quality of products, and C2C mode Taobao dropped to second place。
Indian power market developer also has many years, Indian consumers have begun to mature, they began to pursue a better quality product, which you can see a similar situation from the mobile phone market, as early as two years Indian brands such as Micromax's ultra-low-cost cheap Mobile phones has won significant market share, Micromax more than once made Samsung's position in the market, but this year Chinese mobile phone brands with better quality and higher prices of products has won a substantial share of the smartphone market in India, India's intelligence there are four of the top five mobile phone market come from China, India, the Indian domestic brands was out of the top five smartphone market position。 The combination of these factors to consider, Alibaba stake is no longer considered Indian electricity supplier in the Indian market and chose to support its holding Paytm development, perhaps in the hope that the Indian market will Paytm electronic business platform to become another Lynx。

Location: body of a male contraceptive is coming!Would you like to eat for your girlfriend / wife do 2018-3-2815: 27: 44 Source: Introduction: The way it is。British "Daily Mail" recently broke the news – male contraceptive successfully tested!University of Washington researchers recruited 83 18?50-year-old man, give them to eat one kind of male contraceptive called DMAU, taken once daily for 28 days……Short-acting contraceptives, deep reactive with the name does not mean that eating a pill causes weight gain, Zhangdou, lead to irregular menstruation, and even cancer it?In fact, these claims are out of date。Oral contraceptives, estrogen and progesterone composition。Progestin contraceptives in the past, have androgenic activity, after taking so easy to gain weight, acne。Now using a new type of progesterone, androgen almost no role, and even anti-androgens, not only do not eat no fat Changdou, but also reduce body swelling, breast tenderness and discomfort。Medicine menstruation can contraception, but also tune "Menopathy" Clinically, the doctor gave some female patients, there is a short-acting oral contraceptives。
Oral contraceptives can prevent ovarian cancer will inhibit ovulation, which is equivalent to the chance of ovarian a respite; but also to prevent endometrial hyperplasia, and then develop into cancer。However, despite the short-acting contraceptive benefits, but its greatest adverse reactions, blood clots that may increase the risk of thrombosis high-risk populations (healthy people are not affected)。So the following categories of people, not fit to eat: people smoke; there are serious cardiovascular disease or rheumatic disease of the crowd; people suffering from migraine; diabetes, hyperlipidemia, liver disease crowd; there is a history of breast cancer or are currently people suffering from breast cancer。
In addition, more than 40-year-old woman, and Zhangdou, dysmenorrhea, menorrhagia people, do not just buy food!Like doctor like doctor like doctor!。

  Local time on January 18, 2018, Chinese panda "Hua Panther" and "Golden baby" arrived in the Finnish capital Helsinki-Vantaa International Airport, to carry out a 15-year research cooperation。   To ensure the smooth through the adaptation period after two giant pandas arrived in Finland, China sent an experienced breeder and veterinarian random escorted, they will team with meticulous care and Finland two giant pandas, until two pandas adapt to new home life。   Two giant pandas in the future will stay 芬兰艾赫泰 zoo, which is located in the northern part of the zoo in Helsinki more than 300 kilometers, covering 60 hectares, the climate is similar to the Sichuan Giant Panda Sanctuaries, is Finland's largest wildlife park。
To meet the arrival of giant pandas, the zoo built a cost of 8.2 million euros of the giant panda museum, covering nearly 6,000 square meters, each panda pens about 2,000 square meters, the design philosophy is to provide access to wild habitat for giant pandas surroundings。
  Ahtari zoo in order to promote both Chinese baby, taking into account the Finnish pronunciation in Chinese tell "Leopard" and "treasure" of the tone, then collect the Finnish name for the two giant pandas in the country。
"Pilv" Finnish male name, which means "snow"; "Rumi" is a Finnish female name, meaning "snow"。
Editor: Li Ruichen。